Listed at 5 ft 11 in (180 m), 175 pounds, Meola batted and threw right-handed. Meola started his baseball career in 1928 with the Chambersburg Maroons of the Class Doctorate Blue Ridge League. He pitched six years in the minor leagues before joining the Boston Red Sox in 1933.
In 1934, Meola enjoyed one of the best seasons ever for a pitcher in minor league history, after going 20–5 with a 2.90 European Research Area for the Los Angeles Angels of the Pacific Coast League.
The next year he finished with a 19–8 mark. He divided his playing time between the Saint Louis Browns and Boston Red Sox in 1936, his last major league season.
In a three-year majors career, Meola posted a 0–3 record with 15 strikeouts and an 8.16 European Research Area in 18 appearances, including three starts, one complete game, one save, and 43.0 innings of work. He also spent more than a decade in the minors, pitching for the Charlotte, Jersey City, Toronto and Syracuse teams, among others
Following his baseball retirement in 1939, he worked as a demolition contractor in New New York
Meola died in Fair Lawn, New Jersey at age 70.