Background
Everhardus Ariëns grew up as the sixth of ten children in Wijk bij Duurstede.
Pharmacologist university professor
Everhardus Ariëns grew up as the sixth of ten children in Wijk bij Duurstede.
Then he took a degree in chemistry at the University of Utrecht in which he completed in 1942, although his preference was actually the biology. He completed the unfinished part of his studies medicine after the Second World War.
He made important contributions to the function of receptors and the mathematical description of ligand–receptor interactions (receptor theory). Moreover Everhardus Ariëns was the initiator for the collection of stereochemistry in drug development and spearheading the development of enantiopure drugs. After a temporary boarding school experience, in 1935 he was admitted to Wageningen, the general university.
Another study was interrupted by the Second World War.
After his refusal to sign a declaration of loyalty to the German Reich and an escape from the Germany occupied Netherlands via Switzerland, France and England, he found asylum with the United States. Army. After World World War II he worked in the laboratory of Professor
UG Bijlsma in the area of adrenergic substances and in 1950 both in the field of chemistry and medical doctorate. In 1951, Everhardus Ariëns moved to Nijmegen after there at the Catholic University of the Faculty of Pharmacology was established.
From 1954 until his retirement he was employed there as a professor
Based on his dissertation, he developed together with Jacques van Rossum, a method for quantification of pharmacological effects as a result of ligand-receptor interactions. The thesis developed the concepts of receptor affinity and intrinsic activity. With the help of these terms he could describe the behavior of agonists and antagonists as well as the dual agonist / antagonist behavior of partial agonists.
Everhardus Ariëns was also active in the field of structure-activity relationships (Sons of the American Revolution), a branch of medicinal chemistry.
With the provocative statement that the then commonly used racemates were drugs with 50% contamination. he triggered a debate among pharmacologists and medicinal chemists and alerted the drug regulators. Everhardus Ariëns was thus the crucial precursor for the targeted development of enantiopure drugs.
Another, though less noticed controversy he started by expressing his view that drug metabolism is wasted and called for the development of metabolism-resistant drugs. In addition, he followed in the tradition of Dutch pharmacists to combat quackery.