Education
Maryanoff received a Bachelor of Surgery degree in chemistry in 1969, and a Doctor of Philosophy degree in organic chemistry in 1972, both from Drexel University.
Maryanoff received a Bachelor of Surgery degree in chemistry in 1969, and a Doctor of Philosophy degree in organic chemistry in 1972, both from Drexel University.
From 1972 to 1974 Maryanoff was a postdoctoral fellow in the Department of Chemistry at Princeton University. He joined McNeil Laboratories, Incorporated., a Johnson & Johnson subsidiary, in 1974 and advanced on the scientific ladder in various Johnson & Johnson pharmaceutical units to the highest scientific position in the company. Maryanoff retired from Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania, in January 2010.
Maryanoff has been active in the fields of medicinal chemistry and organic chemistry.
Topiramate is also a principal component of the antiobesity drug Qsymia. Maryanoff is an internationally renowned expert in drug design and drug discovery, especially in the application of protein structure-based drug design.
His drug discovery work led to numerous new chemical entities (NCEs) entering preclinical development, 13 of which advanced into human clinical trials. He made seminal contributions to understanding the stereochemistry and mechanism of the Wittig reaction.
Adapted the cobalt-catalyzed alkyne trimerization to the synthesis of macrocycles.
And devised novel peptides that undergo self-assembly to mimic native collagen structurally and functionally. Maryanoff is an author on 275 scientific publications, including several books (editor), book chapters, and review articles He is an inventor on 100 issued United States. patents, has presented over 180 invited lectures worldwide, and mentored 11 postdoctoral associates.
Maryanoff organized and edited a special memorial issue of the Journal of Medicinal Chemistry to honor the memory of Doctor Paul Janssen (2005) and has served on numerous editorial advisory boards for scientific journals and research grant review committees.