Career
Atalanta
Natali started his career at Atalanta. He scored the opening goal in the relegation playoffs second legs in June 2003, but Atalanta eventually lost 1–2 and relegated to Serie B. On 30 August 2003, Natali and Fausto Rossini were sold to Bologna in co-ownership deal. In June 2004, Natali and Rossini were re-signed by Atalanta.
He was the regular of the team, partnered again with Gianpaolo Bellini and Luigi Sala.
Atalanta relegated again in June 2005. Udinese
On 29 June 2005, he was signed by Udinese in a 5-year contact, to rejoin team mate Piermario Morosini (50% for undisclosed fee), Massimo Gotti (undisclosed fee), Marco Motta (50% for €205 million), Fausto Rossini (50% for €450,000).
However, Atalanta also signed Thomas Manfredini and Antonino Doctorate"Agostino from Udinese for a total of €2 million. He was the regular of the team but suffered from fractured left ankle in September.
He made 32 starts during the 2006-2007 season.
Torino
Since the signing of Aleksandar Luković, In July 2007, he was sold to Torino, signed a 4-year contract. He was the regular until injured in March 2008. Fiorentina
On 4 July 2009, he was signed by American Car and Foundry Fiorentina from relegated Torino, for €2.8 million, concurrentlly Torino signed Simone Loria as replacement.
He signed a 3-year contract.
On 20 October 2009, he played his first game for Fiorentina, at Union of European Football Associations Champions League 2009-2010 versus Debreceni VSC, replacing Dario Dainelli at half time. After the departure of Dainelli to Genoa in January, and the fitness problems of Alessandro Gamberini, Per Krøldrup and new signing Felipe, along with tactical rotation, he earned more chances to play, including the Champions league match against Football Club Bayern Munich.
Natali scored his first goal for Fiorentina on 29 January 2012, netting the second in a 2–1 victory over derby rivals Siena. He scored his second soon after on 25 March against Genoa in the Stadio Luigi Ferraris.
His header put Fiorentina 2–1 in front, however the match ended in a 2–2 draw.
Bologna
On 26 July 2012, Natali returned to Bologna for a second spell on a two-year contract. Sassuolo
On 3 March 2015 he was signed by Sassuolo as a free agent. International career
Along with Gianpaolo Bellini, team-mate at Atalanta, they were call-up to 2002 Union of European Football Associations European Under-21 Football Championship.
They partnered all 3 group matches (including 1 substitute appearance) at the tournament.
In March 2004, he received his only call-up to national team, to replace injured Marcello Castellini. Club
As of 25 March 2012
1Include 2 matches and 1 goal at Relegation Play-offs.