Career
He was Bishop of Cordoba, (August 1516 - 1523), and Archbishop of Seville (from August 1523). He was Inquisitor general (September 1523 onwards) as a successor of Adrian of Utrecht (later Pope Adrian VI), and appointed around February - April 1531 as cardinal-priest of the Santi Apostoli, Rome. After he was given the title of cardinal-priest of San Callisto, from 17 April 1531 till 12 July 1532.
He died on 28 September 1538 in Seville after falling from a horse.
Manrique was born in Segura de León in Badajoz, apparently a son from the third marriage of the famous Rodrigo Manrique with a Solís-Castañeda woman, (1404 - Ocaña, 1476), being therefore a very young stepbrother of the poet Jorge Manrique de Lara, (circa 1440 - 1479, died besieging the castle of Garcimuñoz). He died in Seville.