Career
Kedikilwe was educated at the Kikuyu College of Social Studies, the University of East Africa, Nairobi 1963-1964. University of Rochester, New York 1964-1965. University of Connecticut 1965-1968.
Maxwell School of Citizenship and Public Affairs, Syracuse University.
Kedikilwe served as Chairman of the BDP until 2003. Khama had been backed for the post by President Festus Mogae, and the outcome was viewed as crucial, paving the way for Khama to eventually succeed Mogae as President.
Kedikilwe was appointed as Minister of Minerals, Energy, and Water Resources in January 2007. Vice-President Mompati Merafhe retired on 31 July 2012.
President Ian Khama nominated Kedikilwe as Vice-President on 1 August 2012, and the National Assembly promptly approved the nomination.
38 MPs voted in favor, while 12 abstained from the vote. Kedikilwe was sworn in later in the same day. The government said that Kedikilwe would retain his portfolio as Minister of Minerals, Energy, and Water Resources.
Following the 2014 general election, Khama instead nominated Mokgweetsi Masisi as Vice-President on 12 November 2014.