His father was of Irish descent and his mother was of Italian-Albanian ancestry.
Regis Francis Xavier Philbin was born in New York, United States and grew up in the South Bronx. Regis Philbin was the eldest son of Frank, was a marine, and his wife Florence Philbin. Regis Philbin was named after his father's alma mater, Regis High School, a Jesuit boys school in Manhattan. He was married twice. The first one to Kay Faylan from 1955-1968; the couple had two children, Amy (born in 1961) and Daniel (born in 1967). And the second one to Joy Senese in 1970, and they had two daughters, Joanna (born in 1973) and Jennifer (born in 1974).