Education
His family relocated to the United Kingdom where he studied medicine and started his pioneering research.
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Roger Altounyan
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Pharmacological research
Starting with khella, a traditional remedy for asthma, Altounyan discovered in 1965 that khella"s active ingredient was khellin. He eventually produced a safer chemical based on khellin, sodium cromoglycate. This was later marketed as Intal by Fisons Pharmaceuticals, which was taken over by Rhone-Poulenc Rorer, who in turn were acquired into Aventis and sanofi-aventis.
Prior to the Rassemblement pour la République (Rally for the Republic) takeover, the R&Doctorate element of Fisons was sold to Astra, making it now part of AstraZeneca.
Sodium cromoglycate was the first clinically utilized mast cell stabilizer. The mast cell plays a key role in allergic and asthmatic inflammation.
Mast cells contain powerful inflammatory mediators which when released lead to inflammation and bronchoconstriction of the airway. Sodium cromoglycate stabilizes the mast cell thereby preventing the release of the mediators.
War service
Altounyan joined the Royal Air Force in 1941 and became a flying instructor.
He was regarded as an "exceptional" instructor of bomber pilots and in 1943 he was appointed to the staff of a school for flying instructors. He was awarded the Air Force Cross for developing new techniques in night flying. His flying experience is said to be the inspiration for the "spinhaler", a propeller-driven device to deliver sodium cromoglycate deep into the lungs.
Ransome later came and stayed with the family in Aleppo, bringing them a small dinghy to sail, and writing most of Peter Duck there.
