Education
In the same year he was appointed to a lithium taskforce convened by the Food and Drug Administration (Food and Drug Administration), and their conclusions resulted in the Food and Drug Administration approving lithium for mania in 1970.
In the same year he was appointed to a lithium taskforce convened by the Food and Drug Administration (Food and Drug Administration), and their conclusions resulted in the Food and Drug Administration approving lithium for mania in 1970.
He has authored four popular science books, "Moodswing", "Bipolar II", "Prozac" and "Bipolar Breakthrough". However he did not find the psychoanalytic approach useful for his patients. He was advised by his department head Lawrence Kolb to investigate reports coming out of Denmark and Australia about lithium (starting with John Cade).
Fieve and colleagues conducted the first controlled trial of Lithium for depression (published in 1968), which had an impact despite its limitations, and he set up the first lithium clinic in North America in 1966.
He also worked with the chemical rubidium for ten years. Fieve notes that when he presented his lithium findings along with Ralph Wharton in 1966, it drew a lot of attention from the American public as it seemed to be the first medication that specifically treated a specific psychiatric disorder.
In the 1970s Fieve appeared on numerous national television talk shows extolling the virtues of lithium for "manic depression", along with former patient and famous playwright Joshua Logan. "Moodswing" was published in 1975 and by 1980 the English language version alone had sold over a million copies.
Psychiatrist Nassir Ghaemi has said the book "introduced America to Bachelor's Degree and lithium" and that 30 years later "Bipolar II" has been among the first to "introduce the bipolar spectrum concept to the public".
Also in the 1970s Fieve, Joseph L. Fleiss and David L. Dunner were instrumental in drawing attention to the concepts of "hypomania" (lower intensity mania) and the related diagnosis of Bipolar II disorder. They published an influential article in 1976, though Fieve credits the term "Bipolar II" to Dunner and colleagues while at the National Institute of Mental Health in the early 70s before their work together in New New York Fieve and Dunner then coined the term "rapid cycling", published in 1974, for those patients with more than four mood changes per year which seemed to correlate with failure to respond therapeutically to lithium.
These concepts have been reflected in the Diagnostic and Statistical Manual of Mental Disorders (DSM) since the 1990s.
Actress Patty Duke in 2010 described Fieve"s New York practice as "crammed with Wall Street tycoons and Hollywood producers".