She graduated from the Royal College of Art with an Master of Arts, in 1981.
She lives and works in her Kent cottage, producing extremely large paintings on unstretched, unprimed canvas, creating a kind of artlessness. In 2010 Wylie was the only non-American artist represented in the Women to Watch exhibition at the National Museum of Women in the Arts, Washington District of Columbia. In 2012, she had a retrospective at Jerwood Gallery, Hastings, followed in 2013 by an exhibition at Tate Britain, London that featured recent works. Tate Shots - Rose Wylie (2013)
Jerwood Gallery: An Afternoon with Rose Wylie.
By Adolfo Doring (2013)
At Home with Rose Wylie, Frieze Video.
In February 2015 she became a member of the Royal Academy of Arts (Research Associate Elect).