He graduated from the applied chemistry course, Engineering Department, Tokyo University in 1889.
Santei Shimizu became chief technician at the Hokkaido Cement Company. He adopted the German dry method of cement manufacturing in preference to the British wet method which was then popular.
In 1894 he was appointed a judge at the Patent Bureau and became president of the Mikawa Cement Company in 1896. In 1900, he was elected a member of the Japan Portland Cement Technology Society. He was executive of the Chuo Cement, Cement Industry and other companies and instructor at the Tokyo Higher Technical School.