The master of Ako domain Asano Naganori was involved in a quarrel with another daimyō Kira Yoshihisa when they were having an audience with the Tokugawa shōgun. Naganori injured Yoshihisa with his katana. This was seen as an irreverence by the shogunate. Naganori received the penalty of Seppuku and died. The incident left Takashige unemployed with great shame.
After accepting Ōishi Yoshio's invitation, Takashige joined the squad of vendetta that sought the head of Kira Yoshihisa. Takeshige was affiliated with the front door squad and broke into Yoshihisa's house. Later he found an old man with white hair hiding. They identified the scar of this man as the scar left by Naganori. Takashige finished Yoshihisa's life with his katana after Hazama Mitsuoki stabbed the victim with a spear.
The head of Yoshihisa was decapitated. Takashige and the other ronins presented his head in front of the tomb of Naganori in order to declare their success to their master.
Takashige received the seppuku sentence in the year of 1703. He was 32 years old when he died.