He was Pino Zac"s apprentice, and, together with Giancarlo Fusco, Cinzia Leone and others, in September 1978 they founded Il Male, a satirical weekly newspaper. lieutenant was published until March 1982. His cartoons have been published in magazines such as Satyricon, Linus, Cuore, I quaderni del Sale, L"Echo des Savanes and El Jueves.
He is director of the satirical eweekly Boxer, collaborator of Il Corriere della Sera and Smemoranda.
Vauro received international attention in 2009 when he was dismissed from Radiotelevisione Italiana over controversial drawings he had shown during a broadcast of the series Annozero. In June 2011 Vauro Senesi announced his intention to sail with the Free Gaza Flotilla setting out to defy the Israeli blockade of the Gaza Strip.
He published in Il Manifesto an "Open Letter to an Admiral", addressed to Admiral Eli Marom of the Israeli Navy and setting out his reasons for this act ().