Student, Northcentral College, 1975. Bachelor of Science, Kalamazoo College, 1977. Doctor of Philosophy, University Chicago, 1981.
Research chemist central research and development department DuPont, 1981-1990. Research leader biotechnology DuPont Merck Pharmaceutical Company, 1990-1992, research fellow structural biology, 1992-1994, senior director medicinal chemistry department, 1994-1995. Professor department biochemistry and biophysics University Pennsylvania School Medicine, Philadelphia, since 1996.
Sloan visiting lecturer department chemistry Harvard University, Cambridge, Massachusetts, 1987. Adjunct professor department biophysics Johns Hopkins Medical School, 1987-1989. Member bioorganic study section National Institutes of Health, since 1997.
Fellow American Association for the Advancement of Science. Member National Academy of Sciences, American Academy Arts and Sciences, Protein Society, American Chemical Society.