He graduated from Keio University.
Yosaburo Takegoshi drifted into journalism (1887) and was associated for a while with several magazines in Osaka for which he wrote leading articles under the pen name of Sansha. He soon gained fame as a historian by authoring several books on the subject.
Along with this, and with the assistance of Kimmochi Saionji and Munemitsu Mutsu he published and edited a magazine called "Japan and The World". In 1900 he was appointed a councilor at the Ministry of Education and the following year was elected a member of the Diet.
In 1907 he became a director of the Yomiuri Shimbun (newspaper). He ran again for the Diet in 1919 but was unsuccessful and he went back to writing history books. Among his works are: "History of Japanese Economics", "New Japanese History" and a biography on Prince Saionji. He was elected a member of the House of Peers in 1923.