In 1973 he received his Master’s degree in Law from the University Paris 1 Panthéon-Sorbonne, in 1974 he finished his Postgraduate degree in International Public Law, Master of Political Science,from the University Paris 1 Panthéon-Sorbonne, and in 1975 he earned his Postgraduate degree in Political Science,from the University Paris 1 Panthéon-Sorbonne.
He has been regarded as relatively hawkish on interest rate policy. On 19 March 2008, Mersch admonished banks for inappropriate risk management, but perhaps more unusually struck a doveish tone with regard to the future path of the European economy. In late June, 2011, speaking while at the annual general meeting of the Bank for International Settlements in Basel, Mersch said, "it is chaos," when asked what would happen if Greece were to default on its debts.
He was described as "a key member" of the ECB Governing Council in the report.
Elected Company-Chair of the Financial Stability Board’s Regional Consultative Group for Europe (2011-2012)
President of the Fondation de la Banque centrale du Luxembourg (Bachelor of Civil Law’s Foundation) which promotes research and higher education in the Bachelor of Civil Law’s fields of activity (2011-2012)
Deputy Chair of the Governing Board of the International Islamic Liquidity Management Corporation (Institute for Integrated Learning in Management) (2010-2012)
President of the non-profit association, The Bridge Forum Dialogue a.s.b.l, founded in 2000 with the participation of the European Union institutions and bodies established in Luxembourg (2000-2012)
Alternate Governor for Luxembourg on the Board of Governors of the International Monetary Fund (International Monetary Fund)(1998-2012).
He has been a member of the European Central Bank"s Executive Board, succeeding José Manuel González Paramo, since December 2012. Since both Governors of National Central Banks and members of the Executive Board of the European Central Bank sit on its Governing Council, Mersch has been a member of the Governing Council since its beginnings. Mersch studied international law in Paris and is member of the Luxembourgish Barometer
Member of the Board of the Luxembourg School of Finance Foundation (FLSF) (2006-2012).
Married Tengku Khatijahbte Ahmad. 2 children.