She is best known for her collaborations with composer Antonio Vivaldi, who wrote several operatic roles for her. Girò"s father was a French barber and wig manufacturer. She began to study with Vivaldi around 1720.
She made her debut at Treviso in the fall of 1723, and in 1724 debuted on stage in Venice, performing Laodice by Tomaso Albinoni.
She sang for Vivaldi starting with her 1726 appearance in his opera Dorilla in Tempe. Vivaldi"s contemporaries and modern scholars have speculated on the nature of the relationship between Vivaldi and Girò, but Vivaldi insisted the relationship was purely artistic.
Girò was prima donna on dozens of performances through her career.