She started her career at age 18 on the daytime soap opera Another World.Heche gradually obtained supporting roles in feature films such as I Know What You Did Last Summer and Volcano (both 1997). Her first leading role was in Six Days Seven Nights (1998)—which has remained her most high-profile film role to date. That same year, she starred in the critically acclaimed film Return to Paradise, which was her second (and last) leading role in a theatrical film to date. Following a supporting role in John Q. (2002), she was nominated for a Primetime Emmy Award for her performance in the TV movie Gracie's Choice (2004). From 2006 to 2008, she starred in her own TV series, Men in Trees. Her most recent film credits include Spread (2009), The Other Guys (2010), and Cedar Rapids (2011). She had a supporting role in the 2009–2011 HBO cable TV series Hung.