Career
He served as interne des hôpitaux in Paris, earning his medical doctorate in 1895 with a thesis on cancer titled Recherches sur la question du cancer. From 1894 to 1899 he focused on physico-pathological studies of microbial poisoning at the Pasteur Institute in Paris. In 1899–1900 he served under Maurice Nicolle (1862–1932) as chief of anti-rabies services at the institute of microbiology in Constantinople.
Afterwards he was associated with research done at the Pasteur Institute in Paris.
Following the death of Emile Roux (1853–1933), he was appointed manager of anti-rabies services. Marie is known for his research involving the action of tetanus toxin on the nervous system, as well as studies of tuberculosis and rabies.
In the 1910s he demonstrated that natural and synthetic suprarenin had the ability to neutralize diphtheria and tetanus toxins. His investigations of rabies led to the development of new vaccination processes.
With Jean Cantacuzène (1863-1934), he published two articles on gastrointestinal cholera.
He died on 29 March 1935 in his laboratory at the Pasteur Institute.