Accola was born in Houston, Texas but she grew up in Edgewood and attended Lake Highland Preparatory School
Accola has guest appeared in a number of television series such as How I Met Your Mother, Supernatural and Drop Dead Diva. In July 2009 Accola starred in the Independent Horror film Deadgirl which centers on two high school boys who discover an immortal woman in an abandoned asylum. That same year again Accola had a bit-role in The Hannah Montana Movie. In 2009 Accola was cast in The CW television series The Vampire Diaries as Caroline Forbes a teenage vampire. The series was an immediate success with the series premiere reaching over 3.6 million viewers.
Both her parents are active members of the local Republican political party.