He graduated Bachelor of Arts in 1568, in Master of Arts
On 16 March 1565 he entered Saint John"s College, Cambridge where he was a contemporary of William Morgan, the bible translator. 1571, and was a Fellow in 1570. On 14 March 1573 he became rector of Festiniog, with its chapelry of Maen Twrog, and on 5 November 1576 archdeacon of Merioneth.
About the same time, he became chaplain to Sir Henry Sidney, lord president of Wales.
On 16 April 1580 there was added to the living he already held the rectory of Llanenddwyn with its chapelry of Llanddwywe, and on 8 October 1602 he was made a canon cursal (second canonry) of Street Asaph Cathedral. He died in 1624, and was buried in Maen Twrog church.
There is a memorial to William Morgan and Edmwnd Prys in Street John"s College Chapel, Cambridge, where they were students.