Background
Isaac Ott was born on November 30, 1847, in Northampton County, Pennsylvania, the son of Jacob and Sarah Ann LaBarre Ott.
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Isaac Ott was born on November 30, 1847, in Northampton County, Pennsylvania, the son of Jacob and Sarah Ann LaBarre Ott.
Isaac Ott studied at Lafayette College, Easton, Pennsylvania, receiving his degree of A. B. in 1867, and the next year entered as a medical student at the University of Pennsylvania in Philadelphia, where he received the degree of M. D. in 1869. After a few years of practical experience he went abroad for further study and attended lectures at the Universities of Leipzig, Wurzburg, and Berlin.
Isaac began the practice of medicine at Easton, Pennsylvania, and always considered that place his home although he was frequently called away by the numerous positions that he held. He was resident physician of St. Mary's Hospital in Philadelphia during the year 1871. After a few years of practical experience he went in Germany for further study. He was for a time lecturer in physiology at the University of Pennsylvania (1878 - 79) and in 1879 a fellow in the biology department of John Hopkins University in Baltimore. In 1894 he became professor of physiology in the Medico-Chirurgical College in Philadelphia, and during 1895-96 was dean of the College but resigned that office, preferring to devote more time to his practice, teaching, research, and writing. In addition to his practice in Easton and his teaching in Philadelphia, Ott was for many years consulting neurologist to the Pennsylvania Asylum in Norristown. He resigned from the faculty of the Medico-Chirurgical College two years before his death but continued to be director of laboratories. His death, caused by pneumonia, occurred at his home in Easton.
Ott was not only a successful practitioner and teacher but he found time for extensive researches. He studied the actions of medicines on the human body and the effects of certain drugs, particularly the alkaloids which act as depressants or stimulants, such as cocain, veratria, gelsemium, lobelina, lycoctonine, and the-baine. Under the general title of "Contributions to the Physiology and Pathology of the Nervous System" he published at different times a series of twenty neurological papers, among them an account of the retrograde and lateral movements with hypnotism; and a report of the effect of section of the spinal cord on the excretion of carbonic acid. His later researches were devoted to the endocrine secretions and the thermogenetic centers of the brain. He is credited with the discovery of the hormone of milk secretion. Also he was the first scientistto demonstrate that injury to the corpus striatum causes a rise in heat production and body temperature.
Ott’s papers on his thermogenetic researches include: A New Function of the Optic Thalami (1879), in collaboration with G. B. W. Field; The Heat-Centre in the Brain (1887); The Four Cerebral Heat-Centres (1887), in collaboration with W. S. Carter; The Thermo-Inhibitory Apparatus (1887), with Charles Colmar; and Thermogenetic Apparatus: Its Relation to Atropine (1887), also with Charles Colmar; and The Heat-Centres of the Cortex Cerebri and Pons Varolii. His other writings include: Action of Medicines (1878); Modern Antipyretics (1891); Textbook of Physiology (1904); and Internal Secretions (1910).
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Isaac Ott was a member of the American Physiological Society; the American Neurological Society; German Medical Society of New York; Philadelphia Neurological Society; and the American Society of Naturalists.
Isaac Ott married Katherine Wykoff on October 14, 1886.