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James Lafayette German, III Edit Profile

researcher , human geneticist educator

James Lafayette German, III, American human geneticist educator, researcher. Recipient numerous grants National Institutes of Health, National Science Foundation, American Cancer Society, New York Community Trust, since 1963.


III, James Lafayette German, was born on January 2, 1926 in Sherman, Texas, United States. Son of George J. and Mary (Davis) G.


Bachelor of Science, Louisiana Polytechnic Institute, 1943. Doctor of Medicine, Southwestern Medical College, Dallas, 1949. Doctor of Medicine (honorary), University Essen, Germany, 2000.


Intern Cook County Hospital, Chicago, 1949-1951. Resident Veterans Administration Hospital, McKinney, Texas, 1952-1955. Clinical associate National Institute Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, 1956-1958.

From research associate to assistant professor Rockefeller Institute and University, New York City, 1958-1963. Associate professor, professor genetics Cornell University Medical College, since 1963, director, organizer division human genetics (pediatrics), 1963-1968. From investigator to member New York Blood Center, 1968-1998, director Laboratory Human Genetics, 1968-1996.

Professor department pediatrics Cornell University Medical College, since 1998. Lieutenant United States Naval Reserve, 1943-1946.


  • Achievements include the experimental production in rodents of the pathognomonic lesion of lupus erythematosus. Finding the first example of genetically determined genomic instability (in the human disorder Bloom's syndrome). Development and maintenance over half a century of the Bloom's Syndrome Registry.

    Obtaining (in Bloom's syndrome) support for Boveri's theory that chromosome mutation is a cause of cancer. Demonstration that somatic crossing-over can take place in mammalian (human) cells. Finding that trimethadione is a human teratogen.

    Advancing the stress (heat-shock) hypothesis of human teratogenesis. And, with colleagues, original observations in human cytogenetics. The molecular isolation of the Bloom's syndrome gene.

    And, the demonstration that the primary defect in Bloom's syndrome is the absence of the activity of the protein Bureau of Land Management, a DNA helicase.


Member American Society Cell Biology, American Society Clinical Investigation (emeritus member), American Society Human Genetics (board directors 1964-1967), Genetics Society America, Harvey Society, Henry Kunkel Society, Marine Biological Laboratory (corporation member).


Married Margaret Fohring, January 14, 1956. Children: James L. IV, Ann Elizabeth.

George J. G.

Mary (Davis) G.

Margaret Fohring

James L. IV III

Ann Elizabeth III