He went to London in 1816, but returned to Germany in 1820 after business adventures and stock speculations fell through. Here he invested in enterprises like textile-trade (1820-1824), mining industry and railways in the thirties and forties of the 19th century, but with limited results. Meyer operated very successfully as a publisher, employing a system of serial subscription to publications, which was new at that time.
To this end he founded a company, Bibliographisches Institut, in Gotha in 1826.
lieutenant published several editions of the Bible, works of classical literature ("Miniatur-Bibliothek der deutschen Classiker", "Groschen-Bibliothek"), atlases, the world in pictures on steel engravings ("Meyers Universum", 1833-1861, 17 volumes in 12 languages with 80,000 subscribers all over Europe), and an encyclopaedia, ("das Grosse Conversations-Lexikon für die gebildeten Stände". See Meyers Konversations-Lexikon, 1839-1855, 52 volumes).
His company grew substantially, and in 1828 he moved it from Gotha to Hildburghausen, where he died thirty years later.