Background
Korochkin, Leonid Ivanovitch was born on April 16, 1935 in Novokuznetzk, Kuzbass, Russia. Son of Ivan Gzigorievitch and Antonina Vasilievna (Talakova) Korochkin.
(Since the Russian edition of this book was published in 1...)
Since the Russian edition of this book was published in 1975 many new research works have appeared which have made necessary some additions for the English edition, to reflect progress in molecular developmental genetics. Recent important findings in this field have brought about essential corrections to the concept of genetic regulation of the process of cell differentiation. The discovery of the mosaic structure of a gene prompted the re evaluation of our considerations about the regulation of gene activity in eukaryotes, and the data about transcriptional events during ontogenesis are of great importance as well. Formerly it was generally accepted that a derepression of genes was responsible for cell differentiation in the process of develop ment. Recently three important conclusions have been derived (Davidson and Britten, 1979) which help to pose the problem in a new way: 1) Only a small part of single copy sequences of DNA is represented in nuclear RNA of a given type of cell or tissue: 10% to 20% in sea urchin embryos, 11 % in rat liver, 4% to 6% in Drosophila cell culture, etc. Since only about 10% of single copy sequences represent the structural genes (Davidson and Britten, 1973), transcription of almost the whole set of structural genes occurs.
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Korochkin, Leonid Ivanovitch was born on April 16, 1935 in Novokuznetzk, Kuzbass, Russia. Son of Ivan Gzigorievitch and Antonina Vasilievna (Talakova) Korochkin.
Doctor of Medicine, Medical Institute, Tomsk, Russia, 1960. Kand. Biological Sciences, Medical Institute, Tomsk, Russia, 1961. Dr.Med.Sci., Medical Institute, Tomsk, Russia, 1968.
Head of laboratory, Medical Institute, Tomsk, 1962-1964;
head of laboratory, Institute Cytology and Genetics, Novosibirsk, Russia, 1965-1979;
head of laboratory, Institute Developmental Biology, Moscow, since 1980;
head of laboratory, Institute Gene Biology, Moscow, since 1991. Visiting scientist Karolinska Institute, Sweden, 1972, Yale University, New Haven, 1990. Professor George Mason U., 1996, U. La Korunja, Spain, 1997.
Consultant Institute Philosophy, Moscow, since 1986.
(Since the Russian edition of this book was published in 1...)
Member Russian Academy of Sciences (correspondent), Russian Academy Natural Sciences (academician).
Married Liubov Sergeevna Klimovitch, April 22, 1961 (divorced January 1985). Married Galina Valerievna, Pavlova, June 7, 1991. Children: Alexandra, Antonina.