She painted portraits and historical subjects in oil and pastel, including portrait miniatures, among them, Bacchus and Ariadne and Angelica and Medoro. lieutenant is a copy after a picture by the artist"s husband, Pierre Subleyras, a picture now in the Louvre, Paris. Maria Tibaldi Subleyras presented this copy to Pope Benedict XIV, who sent her a thousand scudi, and placed her work in his collection at the capitol."
Her sisters, Teresa and Isabela were also artists in the same genre.