Trained in the old Dutch tradition, she turned to Impressionism in her later years. Molly Cramer came from a wealthy merchant family in Hamburg. In 1890 she went to Antwerp to train under Eugène Joors, who taught in the tradition of the Dutch school.
She primarily painted floral still lifes with him.
Back in Hamburg, she attracted the attention of the art gallery director Alfred Lichtwark as a painter of flowers and fruit. In line with Lichtwark"s intentions she worked primarily with the local flora rather than reproduce the overly popular, formulaic Makartbouquets (bouquets of artificial or dried flowers used for decoration, popular in Hans Makart"s style of interior design).
From 1898, Cramer turned her attention to new subjects and worked on landscapes and portraits. Her style now became impressionistic.
Nevertheless, floral still lifes still remained the focus of her work.
Both Cramer sisters exhibited their paintings together with them, but were not part of the Artists" Club. In return, the Cramers" house became a meeting place for artists and art lovers. In addition, Molly Cramer promoted young artists by buying their works and also funded study tours for Ernst Eitner.
Cramer exhibited her paintings in Moscow, Budapest, London, and Chicago.
Towards the end of her life she suffered a decline in her standard of living and was forced to sell paintings from her collection. She eventually lived with a younger relative and died on 18 January 1936 in Hamburg.
The tombstones of Helene and Molly Cramer are at the Hamburg Ohlsdorf Cemetery in the Garden of Women.