Background
Uriah was born on May 2, 1832 in West Wilton, New Hampshire, United States, the son of Samuel and Rebekah (Spaulding) Smith, and the great-grandson of Uriah Smith, who was in Wilton as early as 1778. Samuel was a highway builder and contractor.
As a youth of twelve, Uriah came into contact with William Miller and his followers, who expected Christ's return to earth on October 22, 1844, and the religious excitement of those days made a profound impression on him. His mother embraced the views taught by the Adventists and continually strove to guide her children into a deep Christian experience. In early boyhood Uriah contracted a sickness resulting in a "fever sore" on his left leg above the knee, which, when he was fourteen, necessitated amputation of the leg.