Foreign television he is known for playing the role of Martin Brewer on 7th Heaven and the role of Derek Hale on the Music Television series Teen Wolf. Hoechlin began playing baseball at the age of seven. He played infield for Arizona State University and the Battle Creek Bombers of the Northwoods League.
In 2008, he played infield for the University of California Irvine Anteaters.
He began acting at the age of nine. His performance as Michael Sullivan, Junior. in Road to Perdition led to him getting the role of Martin Brewer in the show 7th Heaven in 2003.
He starred in the 2007 David DeCoteau film Grizzly Rage and was in the 2008 movie Solstice. He also starred in an episode of Castle in its second season.
He appeared alongside Owen Wilson and Christina Applegate in the 2011 movie Hall Pass.
He also played werewolf Derek Hale in the television series Teen Wolf. BuddyTV ranked him #3 on its list of "television"s Sexiest Men of 2011".