Vladislav Khrustalev

Background

Khrustalev was born on May 7, 1985, and is Belarusian. His professional and research career has been centered in Minsk, where he has been associated with Belarusian State Medical University and collaborative biomedical research institutions.

Career

Khrustalev began working as a researcher at Belarusian State Medical University in 1999. He later developed an academic and research career in the university's Department of General Chemistry, where he has been identified as an associate professor and head of the department. His research uses computational and molecular-biology approaches to study mutational pressure and nucleotide-usage bias in herpesviruses, HIV, SARS-CoV-2 and other coronaviruses, Zika virus, parvoviruses, adeno-associated viruses, influenza viruses, archaeal genomes, cancer-associated genes, and proteins. His work also addresses protein secondary structure, peptide and epitope behavior, viral evolution, and implications for vaccines, gene-therapy vectors, and antiviral research. He has collaborated with researchers in Belarus, India, Russia, and other countries and has published in journals including Biochimie, Molecular Immunology, Computational Biology and Chemistry, Frontiers in Microbiology, Frontiers in Cellular and Infection Microbiology, Infection, Genetics and Evolution, and The Protein Journal.

Achievements

• Development of research on mutational pressure in herpesviruses, human immunodeficiency virus, archaeal species, and other viral and cellular genomes, including analysis of how nucleotide-composition bias influences genome evolution, protein structure, and antigenic variation.

Works

• journal article

  • The history of mutational pressure changes during the evolution of adeno-associated viruses: A message to gene therapy and DNA-vaccine vectors designers

    (Co-authored analysis of mutational-pressure changes in ad...)

    2020
  • Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure

    (Co-authored research examining how strong mutational GC-p...)

    2009
  • Stabilization of secondary structure elements by specific combinations of hydrophilic and hydrophobic amino acid residues is more important for proteins encoded by GC-poor genes

    (Co-authored analysis of relationships among amino-acid co...)

    2012
  • Conjugation with the Carrier Helped to Reveal acidification-Induced Structural Shift in the Peptide from Phospholipase Domain of Parvovirus B19

    (Co-authored study of an acidification-induced structural ...)

    2024
  • Mutational pressure in genomes of alphaherpesviruses infecting human

    (Co-authored research article analyzing nucleotide substit...)

    2008
  • Study of completed archaeal genomes and proteomes: hypothesis of strong mutational AT pressure existed in their common predecessor

    (Co-authored comparative genomic and proteomic study propo...)

    2010
  • Translation-Associated Mutational U-Pressure in the First ORF of SARS-CoV-2 and Other Coronaviruses

    (Co-authored comparative study of translation-associated C...)

    2020
  • "Protoisochores" in certain archaeal species are formed by replication-associated mutational pressure

    (Co-authored study linking archaeal protoisoc​​hore-like s...)

    2011
  • Structural and antigenic features of the synthetic SF23 peptide corresponding to the receptor binding fragment of diphtheria toxin

    (Co-authored study of the structure and antigenic properti...)

    2015
  • Mutational pressure is a cause of inter- and intragenomic differences in GC-content of simplex and varicello viruses

    (Co-authored study of GC-content, codon-position bias, and...)

    2009
  • Mutational Pressure in Zika Virus: Local ADAR-Editing Areas Associated with Pauses in Translation and Replication

    (Co-authored study of mutational pressure and ADAR-associa...)

    2017
  • The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein

    (Co-authored protein-structure study published in Proteins...)

    2016
  • Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance

    (Author study of the effects of mutational pressure on lin...)

    2010

• Practical manual

  • Introduction to Organic Chemistry

    (English-language practical manual published by Belarusian...)

    2018

Connections

Khrustalev's recorded family relationship is with his mother, Alena.

Mother:

Alena

Khrustalev's mother.

References

• PubMed author-linked research records Indexes Khrustalev's biomedical research publications and author affiliations.
• ScienceDirect author profile Identifies Khrustalev's affiliation with Belarusian State Medical University and records his publications in molecular biology, virology, protein science, and related fields.